Scientists have never agreed on when humans began wearing clothes and estimates suggested by various experts have ranged greatly, from 40,000 to as many as 3 million years ago.
Recent studies by Ralf Kittler, Manfred Kayser and Mark Stoneking—anthropologists at the Max Planck Institute for Evolutionary Anthropology—have attempted to constrain the most recent date of the introduction of clothing with an indirect method relying on lice. The rationale for this method of dating stems from the fact that the human body louse cannot live outside of clothing, dying after only a few hours without shelter. This strongly implies that the date of the body louse's speciation from its parent, Pediculus humanus, can have taken place no earlier than the earliest human adoption of clothing. This date, at which the body louse (P. humanus corporis) diverged from both its parent species and its sibling subspecies, the head louse (P. humanus capitis), can be determined by the number of mutations each has developed during the intervening time. Such mutations occur at a known rate and the date of last-common-ancestor for two species can therefore be estimated from their frequency. These studies have produced dates from 40,000 to 170,000 years ago, with a greatest likelihood of speciation lying at about 107,000 years ago.

Kittler, Kayser and Stoneking suggest that the invention of clothing may have coincided with the northward migration of modern Homo sapiens away from the warm climate of Africa, which is thought to have begun between 100,000 and 50,000 years ago. A second group of researchers, also relying on the genetic clock, estimate that clothing originated between 30,000 and 114,000 years ago.

Dating with direct archeological evidence produces dates consistent with those hinted at by lice. In September 2021, scientists reported evidence of clothes being made 120,000 years ago based on findings in deposits in Morocco. However, despite these indications, there is no single estimate that is widely accepted.

According to Anthropologists and Archaeologists, the earliest clothing likely consisted of fur, leather, leaves, or grass that was draped, wrapped, or tied around the body. Knowledge of such clothing remains inferential, as clothing materials deteriorate quickly compared with stone, bone, shell, and metal artifacts. Archeologists have identified very early sewing needles of bone and ivory from about 30,000 BC, found near Kostenki, Russia in 1988, and in 2016 a needle at least 50,000 years old from Denisova Cave in Siberia made by Denisovans. Dyed flax fibers that date back to 34,000 BC and could have been used in clothing have been found in a prehistoric cave in Georgia.
Definition of clothing and meaning

According to Anthropologists and Archaeologists, the earliest clothing likely consisted of fur, leather, leaves, or grass that was draped, wrapped, or tied around the body. Knowledge of such clothing remains inferential, as clothing materials deteriorate quickly compared with stone, bone, shell, and metal artifacts. Archeologists have identified very early sewing needles of bone and ivory from about 30,000 BC, found near Kostenki, Russia in 1988, and in 2016 a needle at least 50,000 years old from Denisova Cave in Siberia made by Denisovans. Dyed flax fibers that date back to 34,000 BC and could have been used in clothing have been found in a prehistoric cave in Georgia.
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